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Cosmetic Rejuvenation Center is a foremost provider of Neurotoxin treatments in Cleveland, Ohio. We perform FDA approved BOTOX® Cosmetic, Dysport®, and Xeomin® treatments for the temporary reduction of moderate to severe frown lines between the eyebrows, forehead wrinkles and crow’s feet in patients 18 to 65 years of age.


A purified protein, non-surgical, physician administered treatment.


How Botox®/Dysport®/Xeomin® works:

It works by stopping the signal from the nerve to the muscles, ultimately resulting in a reduction of muscle activity and temporarily preventing contraction of the muscles. These treatments are administered via a few tiny injections directly into the muscles that cause those stubborn lines between the brows. It requires no recovery time and causes little discomfort.


Visible results will appear between 2 and 14 days after your treatment, and results can last up to four months. After those four months you will need a follow-up treatment or the area between your brows will eventually go back to its pretreatment appearance. Treatments are typically scheduled three times a year.


BOTOX®/DYSPORT® treatments are best utilized in conjunction with the use of medical grade skincare products. A customized at home skincare regiment will be designed specifically for your needs and lifestyle, to insure, protect and increase your results of each treatment. Ask one of our skincare specialists how you can get started today, on improving the look and overall health of your skin.



XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use, is a prescription medication used to temporarily improve the appearance of moderate to severe frown lines between the eyebrows (glabellar lines) in adults.

XEOMIN® contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinem.



When you squint or frown, the muscles between your brows contract, causing the skin to furrow and fold. Over time, as your skin ages and loses some of its elasticity, these repeated contractions can cause persistent frown lines.

Botulinum toxin type A – the active ingredient in XEOMIN® – acts on nerve endings in muscles to prevent muscle fibers from contracting. By reducing these contractions, XEOMIN® can temporarily reduce the lines on your forehead between your brows. 



XEOMIN® (incobotulinmtoxinA) for injection, for intramuscular use, was proven effective in two randomized, double-blind, multicenter, placebo-controlled clinical trials of 547 healthy, adult patients. The average age of patients in the study was 46 years. Patients received 20 Units of XEOMIN® and were classified as responders if they had a 2-grade improvement on a 4-point scale as assessed by the physician and patient. Using these criteria, treatment success was higher with XEOMIN® than placebo on Day 30 in both studies (60% and 48% vs. 0% for placebo in both studies). Based on these trials, XEOMIN® received FDA approval for aesthetic use in 2011.



If you are an adult with moderate to severe glabeller lines, XEOMIN® may be right for you. Talk to your doctor to discuss the benefits and risks of treatment.

Do not take XEOMIN® if you are allergic to botulinum toxin or any of the other ingredients in XEOMIN®. You should also not take XEOMIN® if you have an allergic reaction to any other botulinum toxin product or have a skin infection at the planned injection site.



Before receiving treatment with XEOMIN® (incobotulinumtonA) for injection, for intramuscular use, you should tell your doctor about all of your medical conditions, including whether you have a disease that affects your muscles and nerves, have allergies to any botulinum toxin product, or have experienced any side effect from any other botulinum toxin in the past.

In addition, tell your doctor about all the medications you take, including prescription and nonprescription medications, vitamins and herbal supplements.

Especially tell your doctor if you have received any other botulinum toxin product in the last four months or in the past. Be sure your doctor knows exactly which product(s) you received and when you received them.



During treatment, which usually takes about 10-20 minutes, your doctor will inject XEOMIN® (incobotulinumtoxinA) for injection, for intramuscular use, into the muscles in your forehead that cause frown lines between your brows. No anesthesia is required; however, your physician may use a topical anesthetic or cold pack to reduce any discomfort.



In clinical trials, some patients observed visible smoothing as early as 3-4 days after injection. The median first onset of effect was less then a week. The maximum effect occurred at 30 days. The typical duration of effect was up to 3 months in clinical trials but may last significantly longer or shorter in individual patients.

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How Can We Help You?

  • Avoid massage or manipulation of the treated area for three to four hours

  • Maintain an upright posture (sitting, standing or walking) for the next several hours

  • Use the treated muscles by forcefully frowning repeatedly for an hour after treatment

  • The effects of your treatment will be evident in five to seven days

  • The results of these treatments are temporary. You will need injections approximately every three to four months to maintain your results

  • Avoid pain relievers, headache or arthritis medications, with the exception of acetaminophen for 24 hours before/after treatment

  • Do not do any heavy lifting, running or aerobic exercise for 24 hours after treatment

  • Avoid treatment of these injections if, you are pregnant or planning on becoming pregnant, or if you are breast feeding

*Results may vary.

Speed up your visit by bringing the Neurotoxins Consent Form when you visit Cosmetic Rejuvenation Center

For complete product information, please visit www.botoxcosmetic.com
Find out more about Brilliant Distinctions, an exclusive rewards program, by visiting www.BrilliantDistinctionsProgram.com
Visit www.dysportusa.com to learn more about Dysport today.